Low Hanging Fruit

Leishmania donovani promastigote screen:
Date: 7/18/2006 : 2160 Microsource compound library including FDA approved drugs and
natural products screened at 1 micromolar against L. donovani promastigotes in an HTS format

L. donovani protocols

For a list of compounds in Microsource Spectrum Collection and known use of compounds, see http://www.msdiscovery.com/spectrum.html


Molecular Profiler (v1.2) Summary

Profile Name:

Profile Date: 10:37 7.18.2006

Molecule Count: 46

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Probe ID Activity RawData PFlag Indicates failure in any of the following criteria: 1. Low plate Z-prime, 2. Low plate Z-factor, 3. Abnormally high % activity, 4. Low PSCORE (Weighted sum of the Bioactive, Toxicity, Available, and ADME scores; positive values are favorable: they are indicative of molecules which have a prior history of bioactivity, low toxicity, high availability, and/or high bioavailability). Records sorted by number of pflags, then percent activity Bioactive Results from a similarity search against a database of known bioactive molecules; the score is the number of unique hits. Toxicity Results from a similarity search against a database of compounds with genotoxicity and cytotoxicity data; the score is the sum of compounds with all negative test results (+1 each), at least one inconclusive test (-0.25), and one or more positive test results (-1 each) Available Results from a similarity search against a database of commercially available molecules; the score is the number of unique hits ADME Results from the application of the ADME Profiler; the score is the sum of the following: REOS violation (-1.0 each), IP and AS model failures (-0.5 each), Lipinski, Oprea, and Ghose violations (-0.25 each), and Suspect Feature and Miscellanous violations (-0.1 each)
1
IDNM:
AB-00130796 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01846MS,H06 Location info: plateid, well
Click HERE For History
%Activ:
100.64 (4.66) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.46 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.26 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1190 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
4
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-2.00
ADMEViols:
5
Click HERE For Hits
2
IDNM:
AB-00130490 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01846MS,D07 Location info: plateid, well
Click HERE For History
%Activ:
100.60 (4.65) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.46 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.26 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1545 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
2.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-0.50
ADMEViols:
2
Click HERE For Hits
3
IDNM:
AB-00130956 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01833MS,G02 Location info: plateid, well
Click HERE For History
%Activ:
99.98 (4.62) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.22 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.43 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1100 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
5.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
20.00
NumAvailHits:
35
Click HERE For Hits
ADMEScore:
-0.25
ADMEViols:
1
Click HERE For Hits
5
IDNM:
AB-00129935 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01820MS,F07 Location info: plateid, well
Click HERE For History
%Activ:
99.91 (4.62) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.81 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.46 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
7494 Fluorescence intensity
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Failed 0 of 4 Flags
DrugScore:
89.00
NumDrugHits:
100
Click HERE For Hits
ToxScore:
2.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
8
Click HERE For Hits
ADMEScore:
-4.10
ADMEViols:
12
Click HERE For Hits
6
IDNM:
AB-00130956 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01845MS,D07 Location info: plateid, well
Click HERE For History
%Activ:
99.91 (4.62) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.31 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.34 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1145 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
5.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
20.00
NumAvailHits:
35
Click HERE For Hits
ADMEScore:
-0.25
ADMEViols:
1
Click HERE For Hits
7
IDNM:
AB-00131545 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01841MS,C10 Location info: plateid, well
Click HERE For History
%Activ:
99.86 (4.62) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.80 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.29 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2230 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
3.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
-3.00
NumToxHits:
3
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-1.60
ADMEViols:
6
Click HERE For Hits
8
IDNM:
AB-00130828 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01832MS,A06 Location info: plateid, well
Click HERE For History
%Activ:
99.33 (4.59) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.22 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.54 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
5770 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
-2.00
NumToxHits:
6
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
6
Click HERE For Hits
ADMEScore:
-0.60
ADMEViols:
2
Click HERE For Hits
9
IDNM:
AB-00131767 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01844MS,B09 Location info: plateid, well
Click HERE For History
%Activ:
99.33 (4.59) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.57 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.57 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
6510 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
3.00
NumDrugHits:
3
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
4.00
NumAvailHits:
5
Click HERE For Hits
ADMEScore:
-3.60
ADMEViols:
10
Click HERE For Hits
10
IDNM:
AB-00130490 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01827MS,G03 Location info: plateid, well
Click HERE For History
%Activ:
98.79 (4.57) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.59 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
51161 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
2.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-0.50
ADMEViols:
2
Click HERE For Hits
11
IDNM:
AB-00130921 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01833MS,C05 Location info: plateid, well
Click HERE For History
%Activ:
92.85 (4.28) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.22 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.43 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
65405 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
3
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-1.85
ADMEViols:
6
Click HERE For Hits
12
IDNM:
AB-00130066 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01822MS,C11 Location info: plateid, well
Click HERE For History
%Activ:
92.52 (4.27) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.62 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.46 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
336984 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
12
Click HERE For Hits
ToxScore:
-0.67
NumToxHits:
3
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
3
Click HERE For Hits
13
IDNM:
AB-00130254 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01824MS,G04 Location info: plateid, well
Click HERE For History
%Activ:
92.13 (4.25) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.61 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
286831 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
3.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-3.45
ADMEViols:
10
Click HERE For Hits
14
IDNM:
AB-00131575 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01841MS,F10 Location info: plateid, well
Click HERE For History
%Activ:
91.66 (4.23) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.80 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.29 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
92775 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
6.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
-1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
6.00
NumAvailHits:
8
Click HERE For Hits
ADMEScore:
-3.50
ADMEViols:
9
Click HERE For Hits
15
IDNM:
AB-00130119 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01823MS,A04 Location info: plateid, well
Click HERE For History
%Activ:
90.33 (4.16) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.60 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.44 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
394955 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
9.00
NumDrugHits:
12
Click HERE For Hits
ToxScore:
-13.42
NumToxHits:
19
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-3.10
ADMEViols:
11
Click HERE For Hits
16
IDNM:
AB-00131380 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01839MS,B11 Location info: plateid, well
Click HERE For History
%Activ:
89.97 (4.15) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.65 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.24 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
68545 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
9
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-0.60
ADMEViols:
2
Click HERE For Hits
17
IDNM:
AB-00131576 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01841MS,F11 Location info: plateid, well
Click HERE For History
%Activ:
86.99 (4.01) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.80 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.29 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
144290 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
57.00
NumDrugHits:
69
Click HERE For Hits
ToxScore:
-13.00
NumToxHits:
14
Click HERE For Hits
AvailScore:
5.00
NumAvailHits:
9
Click HERE For Hits
ADMEScore:
-3.35
ADMEViols:
10
Click HERE For Hits
18
IDNM:
AB-00131556 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01841MS,D11 Location info: plateid, well
Click HERE For History
%Activ:
82.68 (3.80) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.80 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.29 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
191905 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
7.00
NumDrugHits:
12
Click HERE For Hits
ToxScore:
-2.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
7.00
NumAvailHits:
11
Click HERE For Hits
ADMEScore:
-2.75
ADMEViols:
9
Click HERE For Hits
19
IDNM:
AB-00130066 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01846MS,G11 Location info: plateid, well
Click HERE For History
%Activ:
77.55 (3.56) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.46 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.26 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
216810 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
12
Click HERE For Hits
ToxScore:
-0.67
NumToxHits:
3
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
3
Click HERE For Hits
20
IDNM:
AB-00131468 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01840MS,C10 Location info: plateid, well
Click HERE For History
%Activ:
75.44 (3.46) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.74 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.62 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
160500 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
2
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
3
Click HERE For Hits
21
IDNM:
AB-00131697 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01843MS,C06 Location info: plateid, well
Click HERE For History
%Activ:
73.99 (3.39) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.60 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.63 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
209595 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
7.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-0.50
ADMEViols:
1
Click HERE For Hits
22
IDNM:
AB-00131256 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01837MS,F03 Location info: plateid, well
Click HERE For History
%Activ:
73.66 (3.37) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.44 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.54 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
266850 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
-1.00
NumToxHits:
5
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
6
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
1
Click HERE For Hits
23
IDNM:
AB-00129928 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01820MS,E10 Location info: plateid, well
Click HERE For History
%Activ:
73.33 (3.35) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.81 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.46 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1358679 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
2.00
NumDrugHits:
4
Click HERE For Hits
ToxScore:
1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
5
Click HERE For Hits
ADMEScore:
-0.35
ADMEViols:
2
Click HERE For Hits
24
IDNM:
AB-00130254 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01845MS,F03 Location info: plateid, well
Click HERE For History
%Activ:
71.94 (3.29) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.31 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.34 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
158235 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
3.00
NumDrugHits:
7
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
2
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-3.45
ADMEViols:
10
Click HERE For Hits
25
IDNM:
AB-00131390 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01839MS,C11 Location info: plateid, well
Click HERE For History
%Activ:
70.39 (3.21) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.65 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.24 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
201070 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
21.00
NumDrugHits:
24
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
2
Click HERE For Hits
ADMEScore:
-3.00
ADMEViols:
10
Click HERE For Hits
26
IDNM:
AB-00130116 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01822MS,H11 Location info: plateid, well
Click HERE For History
%Activ:
68.54 (3.13) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.62 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.46 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1402092 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
6
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-3.35
ADMEViols:
12
Click HERE For Hits
27
IDNM:
AB-00131183 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01836MS,F06 Location info: plateid, well
Click HERE For History
%Activ:
68.18 (3.11) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.59 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.62 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
248760 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
7.00
NumDrugHits:
9
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
2
Click HERE For Hits
ADMEScore:
-3.75
ADMEViols:
10
Click HERE For Hits
28
IDNM:
AB-00130652 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01829MS,G07 Location info: plateid, well
Click HERE For History
%Activ:
67.42 (3.07) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.56 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.69 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
256465 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
9
Click HERE For Hits
ToxScore:
-1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
5
Click HERE For Hits
ADMEScore:
-0.70
ADMEViols:
4
Click HERE For Hits
29
IDNM:
AB-00129955 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01820MS,H07 Location info: plateid, well
Click HERE For History
%Activ:
65.78 (2.99) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.81 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.46 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1742271 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
3.00
NumDrugHits:
12
Click HERE For Hits
ToxScore:
-5.00
NumToxHits:
5
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-2.20
ADMEViols:
8
Click HERE For Hits
30
IDNM:
AB-00130652 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01845MS,D03 Location info: plateid, well
Click HERE For History
%Activ:
63.45 (2.88) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.31 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.34 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
205890 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
9
Click HERE For Hits
ToxScore:
-1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
5
Click HERE For Hits
ADMEScore:
-0.70
ADMEViols:
4
Click HERE For Hits
31
IDNM:
AB-00131256 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01845MS,F08 Location info: plateid, well
Click HERE For History
%Activ:
56.29 (2.54) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.31 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.34 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
246090 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
10
Click HERE For Hits
ToxScore:
-1.00
NumToxHits:
5
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
6
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
1
Click HERE For Hits
32
IDNM:
AB-00130116 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01846MS,G03 Location info: plateid, well
Click HERE For History
%Activ:
52.26 (2.35) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.46 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.26 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
452975 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
6
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-3.35
ADMEViols:
12
Click HERE For Hits
33
IDNM:
AB-00130131 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01823MS,B06 Location info: plateid, well
Click HERE For History
%Activ:
51.61 (2.32) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.60 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.44 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1966867 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
13.00
NumDrugHits:
22
Click HERE For Hits
ToxScore:
1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
10.00
NumAvailHits:
17
Click HERE For Hits
ADMEScore:
-3.35
ADMEViols:
13
Click HERE For Hits
34
IDNM:
AB-00130391 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01826MS,E03 Location info: plateid, well
Click HERE For History
%Activ:
51.16 (2.30) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.71 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.50 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1846133 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
12.00
NumDrugHits:
21
Click HERE For Hits
ToxScore:
6.00
NumToxHits:
6
Click HERE For Hits
AvailScore:
44.00
NumAvailHits:
99
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
1
Click HERE For Hits
35
IDNM:
AB-00130392 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01826MS,E04 Location info: plateid, well
Click HERE For History
%Activ:
50.73 (2.28) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.71 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.50 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1862325 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
6.00
NumDrugHits:
6
Click HERE For Hits
ToxScore:
6.00
NumToxHits:
6
Click HERE For Hits
AvailScore:
55.00
NumAvailHits:
100
Click HERE For Hits
ADMEScore:
0.00
ADMEViols:
0
Click HERE For Hits
36
IDNM:
AB-00130441 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01827MS,B04 Location info: plateid, well
Click HERE For History
%Activ:
49.28 (2.21) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.59 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2065487 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
17.00
NumDrugHits:
30
Click HERE For Hits
ToxScore:
1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
15.00
NumAvailHits:
28
Click HERE For Hits
ADMEScore:
-2.60
ADMEViols:
7
Click HERE For Hits
37
IDNM:
AB-00130130 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01823MS,B05 Location info: plateid, well
Click HERE For History
%Activ:
48.02 (2.15) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.60 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.44 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2112792 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
4.00
NumDrugHits:
9
Click HERE For Hits
ToxScore:
5.00
NumToxHits:
5
Click HERE For Hits
AvailScore:
34.00
NumAvailHits:
66
Click HERE For Hits
ADMEScore:
0.00
ADMEViols:
0
Click HERE For Hits
38
IDNM:
AB-00130217 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01824MS,C07 Location info: plateid, well
Click HERE For History
%Activ:
47.94 (2.14) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.61 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1883441 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
50.00
NumDrugHits:
60
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
6
Click HERE For Hits
ADMEScore:
0.00
ADMEViols:
0
Click HERE For Hits
39
IDNM:
AB-00130265 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01846MS,D09 Location info: plateid, well
Click HERE For History
%Activ:
47.78 (2.14) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.46 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.26 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
494830 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
48.00
NumDrugHits:
57
Click HERE For Hits
ToxScore:
-10.00
NumToxHits:
11
Click HERE For Hits
AvailScore:
4.00
NumAvailHits:
8
Click HERE For Hits
ADMEScore:
-3.60
ADMEViols:
11
Click HERE For Hits
40
IDNM:
AB-00131248 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01837MS,E04 Location info: plateid, well
Click HERE For History
%Activ:
47.67 (2.13) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.44 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.54 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
528885 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
81.00
NumDrugHits:
100
Click HERE For Hits
ToxScore:
56.30
NumToxHits:
81
Click HERE For Hits
AvailScore:
36.00
NumAvailHits:
52
Click HERE For Hits
ADMEScore:
-1.25
ADMEViols:
4
Click HERE For Hits
41
IDNM:
AB-00131387 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01839MS,C08 Location info: plateid, well
Click HERE For History
%Activ:
47.65 (2.13) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.65 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.24 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
355040 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
11.00
NumDrugHits:
14
Click HERE For Hits
ToxScore:
-3.00
NumToxHits:
3
Click HERE For Hits
AvailScore:
2.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-0.35
ADMEViols:
2
Click HERE For Hits
42
IDNM:
AB-00130496 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01827MS,G09 Location info: plateid, well
Click HERE For History
%Activ:
47.16 (2.11) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.59 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2151966 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
63.00
NumDrugHits:
100
Click HERE For Hits
ToxScore:
18.00
NumToxHits:
18
Click HERE For Hits
AvailScore:
25.00
NumAvailHits:
51
Click HERE For Hits
ADMEScore:
-0.10
ADMEViols:
1
Click HERE For Hits
43
IDNM:
AB-00028549 ABASE unique identifier
Batch:
BATCH-02 Different batches indicate different locations of molecules with the same composition
LOC:
01824MS,B05 Location info: plateid, well
Click HERE For History
%Activ:
47.12 (2.11) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.61 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1913000 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
13.00
NumDrugHits:
17
Click HERE For Hits
ToxScore:
3.00
NumToxHits:
3
Click HERE For Hits
AvailScore:
64.00
NumAvailHits:
100
Click HERE For Hits
ADMEScore:
-0.35
ADMEViols:
2
Click HERE For Hits
44
IDNM:
AB-00130224 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01824MS,D04 Location info: plateid, well
Click HERE For History
%Activ:
47.01 (2.10) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.61 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1917152 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
2.00
NumDrugHits:
6
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
3.00
NumAvailHits:
4
Click HERE For Hits
ADMEScore:
-1.00
ADMEViols:
4
Click HERE For Hits
45
IDNM:
AB-00130465 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01827MS,D08 Location info: plateid, well
Click HERE For History
%Activ:
46.05 (2.05) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.59 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.36 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2197187 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
16.00
NumDrugHits:
28
Click HERE For Hits
ToxScore:
1.00
NumToxHits:
1
Click HERE For Hits
AvailScore:
14.00
NumAvailHits:
26
Click HERE For Hits
ADMEScore:
-2.60
ADMEViols:
7
Click HERE For Hits
46
IDNM:
AB-00130174 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01823MS,F10 Location info: plateid, well
Click HERE For History
%Activ:
45.48 (2.03) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.60 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.44 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
2215528 Fluorescence intensity
Click HERE For Heatmap
Failed 0 of 4 Flags
DrugScore:
1.00
NumDrugHits:
5
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
4.00
NumAvailHits:
7
Click HERE For Hits
ADMEScore:
-1.50
ADMEViols:
2
Click HERE For Hits
4
IDNM:
AB-00130796 ABASE unique identifier
Batch:
BATCH-01 Different batches indicate different locations of molecules with the same composition
LOC:
01831MS,F04 Location info: plateid, well
Click HERE For History
%Activ:
99.92 (4.62) Percent activity relative to the positive control on the plate, and (ZSCORE), the distance in standard deviations from mean assay activity
ZPrime:
0.14 A measure of discrimination between positive and negative controls in the screen: zprime < 0.0 indicates a failed assay, 0.0 < zprime < 0.5 indicates that the assay discriminates between positive and negative controls, and 0.5 < zprime < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
ZFactor:
0.50 A measure of discrimination between positive controls and the compounds in the screen: zfactor < 0.0 indicates a failed assay, 0.0 < zfactor < 0.5 indicates that the assay discriminates between actives and inactives, and 0.5 < zfactor < 1.0 is ideal (see Zhang, J.BioScreening, 1999)
Click HERE For SAR
FINT:
1275 Fluorescence intensity
Click HERE For Heatmap

Low Plate ZPrime

Failed 1 of 4 Flags
DrugScore:
1.00
NumDrugHits:
4
Click HERE For Hits
ToxScore:
0.00
NumToxHits:
0
Click HERE For Hits
AvailScore:
1.00
NumAvailHits:
3
Click HERE For Hits
ADMEScore:
-2.00
ADMEViols:
5
Click HERE For Hits