T. Brucei kinases

October 10 2005

This data is from a screen of 3118 kinase inhibitors from the ChemDiv library screened at 1 µM against T. brucei brucei blood stream forms in a HTP format. Compounds with greater than 40 % inhibition of cell growth at 44 hours are listed.

Protocol
Summary
Assay Reporter (SAR)
Molecule list in Excel format (compounds)

t

structure	compound id	*% T. Brucei* inhibition**	pubchem info	pub chem bio assays
	AB-00033698	72	IUPAC: 2-(4-dimethylaminoquinazolin-2-yl)phenol
	AB-00050866	72	ZINC00751768,IUPAC: 5-benzyl-8-benzylamino-3-bromo-10-methyl-5,7,9-triazabicyclo[4.4.0]deca-2,6,8,10-tetraen-4-one
	AB-00050901	88	NSC168808, 31541-36-3,ZINC00047956, ZINC01673833,ZINC00047955, ZINC01673832,IUPAC: 3-phenacylidene-1H-indol-2-one	NSC168808, 31541-36-3NCI In Vivo AnticancerDrug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice
	AB-00040367	98	no hits
	AB-00050930	85	none
	AB-00050931	51	BAS 00340056 IUPAC: 7-benzyl-8-[(2-hydroxy-1H-indol-3-yl)diazenyl]-3-methyl-purine-2,6-dione	Gold Collection Apr2005Gold Collection Apr2005 Salt Information: I-
	AB-00050932	69	IUPAC: 2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-3-prop-2-enyl-quinazolin-4-one
	AB-00050971	47	IUPAC: 2-(2,4-dichlorophenoxy)-N-[(5-fluoro-2-hydroxy-1H-indol-3-yl)imino]ethanamide
	AB-00035772	51	ZINC00060293 IUPAC: ethyl 8-amino-3,3,5,5-tetramethyl-7-thia-4-azabicyclo[4.3.0]nona-8,10-diene-9-carboxylate
	AB-00051575	47	none
	AB-00051578	49	IUPAC: (4,9-dimethyl-2-morpholin-4-yl-7-thia-3,5-diazabicyclo[4.3.0]nona-1,3,5,8-tetraen-8-yl)-(3,5-dimethyl-1-piperidyl)-methanone
	AB-00052625	46	ZINC02083072 IUPAC: ethyl 4-[(8,9-dimethyl-2-oxo-3-phenyl-7-thia-3,5-diazabicyclo[4.3.0]nona-4,8,10-trien-4-yl)sulfanyl]butanoate
	AB-00053406	45	IUPAC: N'-[2-(1-cyclohexenyl)ethyl]-N-(3-methylphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
	AB-00053504	48	IUPAC: N'-[2-(1-cyclohexenyl)ethyl]-N-(3-methylphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
	AB-00053645	46	none
	AB-00053647	43	ZINC00756957IUPAC: 4-(4-fluorophenyl)-2-[2-(1-piperidyl)ethylsulfanyl]-6-thiophen-2-yl-pyridine-3-carbonitrile
	AB-00053668	48	IUPAC: tert-butyl 2-[(3-cyano-2-thiophen-2-yl-5-azabicyclo[4.3.0]nona-2,4,10-trien-4-yl)sulfanyl]acetate
	AB-00053671	43	none
	AB-00053678	51	IUPAC: 2-(6-amino-3,5-dicyano-4-thiophen-2-yl-pyridin-2-yl)sulfanyl-N-benzyl-ethanamide